Every post, linked to what it covers.

Fibronectin, the Blood-Brain Barrier, and Alzheimer's

New research frames the blood-brain barrier, via astrocyte fibronectin and APOE4, as the common thread in Alzheimer's.

Research Roundup: Gut Metabolite Reduces Inflammaging

A Bifidobacterium and its metabolite 5-AVAB countered inflammaging in old mice; plus GLP-1 and mitochondria review.

Semaglutide and Lung Fibrosis

A new study on the GLP-1 agonist semaglutide and lung fibrosis, plus GLP-1 receptors in the lungs.

Imidazole Propionate (ImP) and Dementia

A new study links gut-derived ImP to Alzheimer's biomarkers and BBB leakiness; lithium, magnesium, and fiber discussed.

Research Roundup: New Studies Out This Week

Vitamin D plus resveratrol in a Parkinson's mouse model, resveratrol for COPD, and myasthenia gravis longevity.

Aging, Inflammation, and the Failure to Clear Senescent Cells

Mouse study: blocking the PGE2–EP2 receptor restores macrophage clearance of senescent neutrophils; diet and COX2 options discussed.

From Irreversible to Repairable: Reversing Protein Glycation in Aging

A new study engineered an enzyme that removes the advanced glycation end product CML, a previously irreversible aging change.

Brain energy changes in Alzheimer's connect to the benefits of low-dose lithium Paid

A new study on shifting brain glucose use in Alzheimer's, connected to lithium's role in the brain.

Aging at a cellular level

A Nature Medicine study shows cell types and organs age at different rates, including brain and APOE4 findings.

SIRT6 and Reversing DNA Changes in Aging

A study shows boosting SIRT6 restores chromatin organization lost in aging; cyanidin from berries as an activator.

Topical Supplements for Preventing Skin Aging Paid

Studies on topical taurine and resveratrol for skin aging, and her DIY experiment that faded an age spot.

Boosting NAD+ Function While Inhibiting CD38

Why NAD+ declines with age, how inflammation-driven CD38 consumes it, and combining NAD+ precursors with CD38 inhibition.

One Mutation, Ten Extra Years

How a SERPINE1 null mutation lowering PAI-1 is linked to about ten extra years of life in humans.

Research Roundup: Mitigating Sleep Deprivation Paid

Studies on buffering sleep-loss effects, including single-dose creatine for cognition and taurine for skin barrier.

Ketones for heart failure

How shifting the failing heart to ketones and fatty acids improved function in trials of ketone supplements and MCT oil.

Should you eat more meat if you have APOE E4?

A JAMA Network Open study found APOE E4 carriers eating the most red meat had lower Alzheimer's risk.

Your Gut Microbiome as a Cause of Aging Paid

Three counterintuitive mouse studies on the gut microbiome affecting brain aging, memory via the vagus nerve, and intestinal stem cells.

Herpes, Gut Bacteria, and the Brain

Roundup: tau and amyloid as antiviral defense against HSV1, antiviral timing, and gut bacteria reaching the brain via vagus nerve.

Are Motor Neurons the Cause of the Hard Limit on Lifespan?

Examines the theory that motor neuron loss drives sarcopenia and frailty, capping lifespan, and ways to protect motor neurons.

Engineering CAR-T Cells for Alzheimer's

A 2026 mouse study used engineered CAR-T immune cells to target amyloid-beta plaque for removal.

Photobiomodulation to Boost Immune Function

Red and near-infrared light therapy may help T cell function as the thymus declines with age.

Why We Age: Damage, Programmed, or Both?

Compares damage-accumulation, programmed, and information theories of aging to explain what controls the rate of aging.

My Current Supplement Stack for Longevity

Her personal January 2026 supplement stack and the reasoning behind each choice, with caveats.

Reversing Late-Stage Alzheimer's (in Mice)

A mouse study restored brain NAD+ balance with P7C3-A20 to reverse advanced Alzheimer's; current NAD+ options.

Rethinking a Hallmark of Aging: Inflammaging

A study finds inflammaging absent in non-industrialized populations, suggesting it's driven by modern lifestyle rather than inevitable.

Stem Cells, Fatty Acids, and the Biology of Hair Regrowth Paid

A Cell study shows monounsaturated fatty acids activate hair follicle stem cells in mice; oil options discussed.

Arginine and Alzheimer's Prevention

An animal study shows arginine may prevent amyloid-beta plaque buildup; plus other arginine and cognition research.

Alzheimer's Research Points to a New Pathway: SORL1, Exosomes, and microRNAs Paid

A new study links SORL1 mutations, exosomes, and altered microRNAs to underlying Alzheimer's pathology.

Mitochondrial Function and Age-Related Inflammation: Urolithin A

A Nature Aging study suggests urolithin A supports immune cell mitochondria and may slow inflammaging; product testing discussed.

BPIFB4 Longevity Benefits: New Oral Delivery

Background on the centenarian-linked BPIFB4 gene variant and a new study delivering it orally for heart and inflammation benefits.

Research Roundup: Telomeres and Vitamin D3 Paid

Paid roundup: VITAL trial finds D3 slows telomere shortening, 40 Hz stimulation in Alzheimer's, and anti-aging drug trials.

Aging vs. Cancer: Lifespan Constraints

Explores the theory that cancer-prevention mechanisms like telomere shortening and senescence constrain lifespan, and how bowhead whales escape.

Research Roundup: Mitochondrial DNA and Inflammation Paid

Paid roundup: RNA in mitochondrial DNA drives inflammaging, and ubiquinol or D-ribose in heart failure.

Gut Microbiome, Artificial Sweeteners, and Cancer Immunotherapy

A study shows sucralose shifts the gut microbiome, lowering arginine and blunting T cell response to cancer immunotherapy.

Coffee Consumption and Dementia

Sorts through conflicting coffee headlines, focusing on how CYP1A2 caffeine-metabolism variants interact with dementia risk.

Exploring the Supercentenarian: What a 117-Year-Old's Biology Reveals

Multi-omics study of a 117-year-old woman, including a youthful gut microbiome rich in Bifidobacteria.

Research Roundup: Valine Restriction Paid

Paid roundup: valine restriction in mice, bacterial biofilms in arterial plaque, and brain FTL1 in cognitive aging.

Proline for Restoring Mitochondrial Function

A 2024 study shows proline declines with age and restores mitochondrial function; other proline research and sources.

Increasing Oxytocin and Inhibiting TGF-beta to Extend Lifespan

A mouse study combining oxytocin with a TGF-beta inhibitor extended lifespan in old males; natural alternatives explored.

Longevity Research Roundup: HMGB1 and Senescence Paid

Paid roundup: HMGB1 spreading cellular senescence and compounds that counter it, plus thymosin beta 4 in Alzheimer's.

Resilience in Aging: Salutogenesis

Salutogenesis looks at mechanisms that sustain health and resilience in aging, rather than focusing on disease.

Research Roundup: Reversing Physical Signs of Aging Paid

Paid roundup: regrowing tooth enamel, skin and odor changes in aging, and young serum for old skin.

Two Studies Giving Current Hope for Alzheimer's

Creatine for cognition in Alzheimer's and a Nature study framing lithium as a key micronutrient for prevention.

Longevity Research Roundup: BCAAs, Senescence, and More Paid

Paid roundup: BCAAs and cellular senescence, whether whole-food diets matter, and a basal cell skin cancer treatment.

A Gut Metabolite That Drives Atherosclerosis

The microbial histidine metabolite imidazole propionate (ImP) drives atherosclerosis; ways to lower it, like magnesium and Mediterranean diet.

Longevity Research Roundup: 3 Things Paid

Paid roundup: repurposed cancer drugs for Alzheimer's, psilocybin and longevity in mice, and mitochondrial origins of sleep pressure.

Inflammation, Insomnia, and Depression in Aging

A JAMA Psychiatry endotoxin study in adults over 60 examines how inflammation and insomnia together affect depressive mood.

Boosting Mitochondrial Function with Light

How specific light wavelengths interact with mitochondria to produce energy, and what that could mean for healthspan.

Longevity Supplements: How Many Capsules Are You Swallowing?

Why she worries about capsule ingredients like microcrystalline cellulose, HPMC, and pullulan affecting the gut barrier.

FOXO3: The Longevity Gene

Why FOXO3 variants are linked to longevity, what FOXO3 does (autophagy, stress resistance, gut health), and new research.

Klotho: Anti-Aging Superstar

Why Klotho levels predict mortality, how it mitigates inflammation including NLRP3, and ways to increase it.

Sulfur Amino Acid Restriction for Longevity and Weight Loss

Research showing restricting methionine and cysteine, rather than calories alone, drives longevity and weight loss.

Blocking NLRP3 to Decrease Alzheimer's Risk

Large medication datasets point to NLRP3 inflammasome inhibition lowering Alzheimer's risk; natural and drug options reviewed.

Fisetin for Clearing Out Senescent Cells

Research on fisetin as a senolytic flavonoid, its effects on stem cells and inflammation, and dosing in studies.

Blood-Brain Barrier: Key to Longevity and SuperAgers

A Stanford mouse study links a thinning BBB glycocalyx to cognitive aging, paralleling gut mucosal thinning in autodigestion.

Does Nicotinamide Riboside Increase Heart Disease Risk?

A 2024 study links excess-niacin metabolites to cardiovascular events; what that means for NR and NMN.

miRNA Regulation and Aging: The Epigenetic Connection

How microRNAs like miR-34a shift with age, affecting NAD+, muscle, metabolism, immunity, and neurodegeneration.

A New Pathway to Target for Alzheimer's

Reviews Alzheimer's theories, then explores the reelin–APOE receptor pathway, fibronectin genetics, and GSK3β inhibition as targets.

Researchers Untangle an Important Hallmark of Aging: EDA2R

EDA2R rises body-wide with age, driving NF-kB inflammation and muscle wasting; tied back to autodigestion.

Testing My Microplastics Level

Her personal effort to cut plastic exposure and what her blood test showed afterward.

New Study on Slowing Aging: Fish Oil, Vitamin D, and Exercise

A Nature Aging trial tested omega-3, vitamin D, and exercise on epigenetic clocks; why SPMs matter.

GHK-Cu Peptide in Skin, Hair, and Lung Health

What the copper peptide GHK-Cu does, research on skin, hair, and lung repair, plus a reality check.

Longevity for the 99%

Inexpensive interventions—creatine, DHA/EPA, curcumin, hesperidin, quercetin, melatonin—for preventing diseases of aging.

Extending Lifespan with miRNAs

A new study on miR-302b reversing cellular senescence and extending lifespan in mice; what influences its expression.

Epigenetic Aging Due to Mutations

A new study connects accumulating somatic DNA mutations to DNA methylation changes that epigenetic clocks measure.

L-Glutamine for Gut Barrier Function

Glutamine's role in immunity and mucus production, and its connection to autodigestion and microplastics.

Alpha-Ketoglutarate for Longevity

What alpha-ketoglutarate does in energy production and epigenetic regulation, and research on healthspan and lifespan.

Microplastics Are a Real Problem

Why she can no longer ignore microplastics: findings in atherosclerotic plaque, heart events, and brain tissue.

Autodigestion: Are Digestive Enzymes Breaking Down Your Body?

Follow-up on digestive enzymes escaping a thinning gut mucosal barrier, emulsifiers that thin it, and ways to support it.

A New Theory of Why We Break Down in Old Age

A rat study proposes digestive enzymes leak through a thinning gut mucosal barrier, causing autodigestion and inflammation.

Testing What Works for Reversing Biological Age

A preprint analyzes 51 intervention studies against epigenetic clocks to see which interventions shift biological age.

C15:0 (Pentadecanoic Acid): Dietary Sources and Supplement Options

What the odd-chain fatty acid C15:0 is, studies on its levels and health, and dietary and supplement sources.

Minimizing Light at Night, Maximizing Melatonin

A PNAS study of 100,000+ people links night light exposure to mortality; ways to boost melatonin.

Mitigating Microplastic Risk

Microplastics show up in plaque, brain, and tumors; practical ways to reduce exposure.

Alzheimer's Prevention Strategies

Roundup of Alzheimer's pathways—circadian rhythm, fibronectin and the BBB, plasmalogens, oral microbiome—with prevention lifehacks for each.

MOTS-c: The Mitochondrial Peptide That Mimics Exercise

Background on mitochondrial-derived peptides and research on MOTS-c as 'exercise in a bottle.'

New Studies on Preventing Alzheimer's

Two new studies, including dopamine boosting neprilysin to reverse Alzheimer's pathology in mice.

Can Eggs Prevent Alzheimer's?

A study of older adults links dietary choline from eggs to lower Alzheimer's risk; explains choline and acetylcholine.

IL-11 and Extending Healthspan and Lifespan

A Nature mouse study shows blocking the inflammatory cytokine IL-11 extends lifespan and healthspan.

Glycine for Improving Slow-Wave Deep Sleep

Why sleep matters for dementia risk and how glycine at night may improve slow-wave deep sleep.

Gut Microbiota and Alzheimer's Disease

A genetic study links specific gut bacteria to Alzheimer's risk; Bifidobacterium breve as a possible option.

Luteolin: Neuroprotective and Anti-Inflammatory

Research on the flavonoid luteolin for neuroinflammation, microglia, and amyloid-beta, and whether it's worth adding.

Longevity and Genetic Trade-Offs (updated)

Updated look at a study of genetic variants that trade longevity against early-life growth and reproduction.

Epigenetic Tests for Biological Age

How DNA methylation clocks work, circadian effects on methylation, and a study showing biological age tests vary.

Do Microplastics Shorten Lifespan?

Reviews research on microplastic exposure and heart disease, diabetes, and cancer to ask if it matters for healthspan.

Targeting Cellular Senescence with Senolytics

What cellular senescence and SASP are, why excess senescent cells drive inflammation, and senolytic options like fisetin.

TNF-alpha and Inflammaging

How chronically elevated TNF-alpha drives aging-related disease and ways to lower it.

Genetics and Healthspan

A large genetic study shows which variants, led by LPA, most affect healthy years of life.

Serine for Cognitive Enhancement

An animal follow-up on combined metabolic activators with L-serine for cognition in aging.

Methylene Blue and Mitochondrial Function

How methylene blue affects mitochondria and the brain, its dose-response curve, and G6PD caution.

Intermittent Methionine Restriction

A new study on intermittent methionine restriction for healthspan; what methionine does and human evidence.

Preventing Muscle Loss in Aging

Research on exercise, leucine, vitamin D, omega-3s, and stacked interventions to prevent or reverse sarcopenia.

Folate, Folic Acid, and Methylfolate: Is More Better?

Examines claims about high-dose folic acid and methylfolate, MTHFR and DHFR genetics, and possible downsides of excess folate.

Low-Dose Lithium Reduces Cellular Senescence

A study shows low-dose lithium may act as a senolytic via GSK3B inhibition, with implications for aging.

Biggest Impacts on the Aging Brain

A UK Biobank study ranks modifiable dementia risks for vulnerable 'last in, first out' brain regions: alcohol, diabetes, air pollution.

Geroplasticity: Is Rejuvenation of Aging Possible?

A 2022 article argues aging is plastic, describing 'geriatrins' that drive aging and 'rejuvenins' that reverse it.

Plasmalogens and Alzheimer's Prevention

Plasmalogens as the brain's last line of antioxidant defense in Alzheimer's, and dietary and supplement ways to restore them.

Gum Disease Is Linked to Alzheimer's

Specific oral bacteria like P. gingivalis are linked to Alzheimer's; what you can do about oral health.

Spermidine and Healthspan

Research and clinical trials on spermidine and autophagy, and why increasing spermidine can sometimes be a bad idea.

Alzheimer's Trial with 4 Common Supplements

A phase II trial of combined metabolic activators (serine, NR, NAC, carnitine) improved cognitive scores in Alzheimer's patients.

Supplementing with Glycine and NAC (GlyNAC)

How glycine plus NAC restores glutathione, reducing oxidative stress and improving mitochondrial function in older adults.

Stopping Inflammaging: SPMs to the Rescue

Inflammation resolution is an active process driven by DHA/EPA-derived SPMs; research on aging, brain, and dosing.

Longevity and Genetic Trade-Offs

A study of genetic variants linked to both longevity and disease risks, framing lifespan as an evolutionary trade-off.

B Vitamins in Mild Cognitive Impairment

Homocysteine, B vitamins, and brain atrophy in mild cognitive impairment, including genetic variants that matter.

HMB and Vitamin D for Muscle in Aging

A 12-month study of HMB plus vitamin D for muscle mass, strength, and function in older adults.

Taurine Deficiency in Aging

A Science study shows taurine declines with age and supplementation extended lifespan in mice.

Stimulating Neurogenesis, Even in Old Age

How smelling varied odors may stimulate adult neurogenesis via the olfactory bulb and protect against cognitive decline.

Longevity Lifehacks: Preventing Alzheimer's

The first newsletter: introduces Longevity Lifehacks and highlights Alzheimer's prevention research, including metabolic activators and lithium.