Epigenetics & DNA
Aging involves accumulating somatic mutations, shifts in DNA methylation that epigenetic clocks measure, and loss of organized chromatin structure; a new study showed boosting SIRT6 reversed some of these DNA changes.
12 interventions act here
Vitamin D3 (incl. HMB + vitamin D)
Sunlight-made hormone that regulates immunity and muscle; linked to slower telomere shortening and preserved function in trials.
I've used it
Folate & B Vitamins
Methylation-cycle vitamins that lower homocysteine and slowed brain atrophy in MCI, but excess folate may fuel cancer.
In my stack
Omega-3s (DHA/EPA) & SPMs
DHA and EPA are the building blocks for pro-resolving mediators that actively switch off inflammation.
In my stack
NAD+ precursors (NR, NMN) and CD38 inhibition
NR and NMN feed the NAD+ salvage pathway to offset the age-related NAD+ decline driven partly by CD38.
In my stack
Resveratrol
Grape polyphenol in her stack, linked to heart health, lower inflammation, FOXO3/sirtuin activation, and fading age spots.
In my stack
Methionine & Sulfur Amino Acid Restriction
Limiting methionine and cysteine extends lifespan in animals and lowers IGF-1; intermittent versions may spare muscle.
Watching
Proline
Collagen-rich amino acid that restored mitochondrial function in senescent stem cells in a 2024 study.
In my stack
Alpha-Ketoglutarate (AKG)
Krebs-cycle metabolite that drops sharply with age; supplementation extended lifespan and healthspan in mice.
In my stack
Lithium (low-dose lithium orotate)
Trace mineral found in food and water; low brain lithium is linked to Alzheimer's amyloid, tau, and neuroinflammation.
In my stack
GHK-Cu (copper peptide)
Copper-binding tripeptide that declines with age and supports skin, wound healing, hair and lung repair.
I've used it
Urolithin A
Gut-microbe metabolite of ellagitannins that boosts mitophagy and may counter age-related immune decline.
In my stack
Luteolin
Flavonoid from herbs and vegetables with anti-inflammatory, antihistamine, and possibly neuroprotective effects, mostly shown in cells and animals.
Watching