Collagen & extracellular matrix
The extracellular matrix changes with age: AGEs crosslink and stiffen collagen in skin and vessels, escaped digestive proteases can break down matrix, and excess fibronectin scars the blood-brain barrier.
6 interventions act here
Taurine
Sulfur-containing amino acid whose levels decline with age; supplementation extended median lifespan in mice.
I've used it
Curcumin
Turmeric polyphenol that lowers TNF-alpha and other inflammatory signals; she takes it to curb NLRP3 overactivation.
In my stack
Resveratrol
Grape polyphenol in her stack, linked to heart health, lower inflammation, FOXO3/sirtuin activation, and fading age spots.
In my stack
Proline
Collagen-rich amino acid that restored mitochondrial function in senescent stem cells in a 2024 study.
In my stack
Alpha-Ketoglutarate (AKG)
Krebs-cycle metabolite that drops sharply with age; supplementation extended lifespan and healthspan in mice.
In my stack
GHK-Cu (copper peptide)
Copper-binding tripeptide that declines with age and supports skin, wound healing, hair and lung repair.
I've used it