Cellular senescence
Senescent 'zombie' cells stop dividing, which helps prevent cancer, but they pile up with age and secrete inflammatory signals that drive inflammaging; she increasingly favors restoring the immune system's own clearance over senolytics.
7 interventions act here
NAD+ precursors (NR, NMN) and CD38 inhibition
NR and NMN feed the NAD+ salvage pathway to offset the age-related NAD+ decline driven partly by CD38.
In my stack
Curcumin
Turmeric polyphenol that lowers TNF-alpha and other inflammatory signals; she takes it to curb NLRP3 overactivation.
In my stack
Proline
Collagen-rich amino acid that restored mitochondrial function in senescent stem cells in a 2024 study.
In my stack
Fisetin & Quercetin
Plant flavonoids studied as senolytics that clear senescent 'zombie' cells and dampen inflammatory signaling.
In my stack
Alpha-Ketoglutarate (AKG)
Krebs-cycle metabolite that drops sharply with age; supplementation extended lifespan and healthspan in mice.
In my stack
Lithium (low-dose lithium orotate)
Trace mineral found in food and water; low brain lithium is linked to Alzheimer's amyloid, tau, and neuroinflammation.
In my stack
Microplastics Reduction
Cutting nanoplastic exposure, found in arterial plaque and brain tissue, and keeping the gut barrier strong.
I've used it