NLRP3 inflammasome
The NLRP3 inflammasome is an immune sensor that amyloid-beta and tau activate in microglia, setting off IL-1β-driven neuroinflammation; large medication datasets suggest blocking it may lower Alzheimer's risk.
4 interventions act here
Ketones (exogenous ketones & MCT)
Alternative fuel that lets the energy-starved failing heart pump better; BHB also dampens NLRP3 inflammation.
Watching
Omega-3s (DHA/EPA) & SPMs
DHA and EPA are the building blocks for pro-resolving mediators that actively switch off inflammation.
In my stack
Curcumin
Turmeric polyphenol that lowers TNF-alpha and other inflammatory signals; she takes it to curb NLRP3 overactivation.
In my stack
Fisetin & Quercetin
Plant flavonoids studied as senolytics that clear senescent 'zombie' cells and dampen inflammatory signaling.
In my stack