NAD+
NAD+ is a coenzyme that powers mitochondrial energy, DNA repair, and immune function; she notes levels fall 50% or more by age 60 as CD38 (inflammation) and PARP use more of it and production drops.
3 interventions act here
NAD+ precursors (NR, NMN) and CD38 inhibition
NR and NMN feed the NAD+ salvage pathway to offset the age-related NAD+ decline driven partly by CD38.
In my stack
Fisetin & Quercetin
Plant flavonoids studied as senolytics that clear senescent 'zombie' cells and dampen inflammatory signaling.
In my stack
Luteolin
Flavonoid from herbs and vegetables with anti-inflammatory, antihistamine, and possibly neuroprotective effects, mostly shown in cells and animals.
Watching