Mitochondria & energy
She treats mitochondrial dysfunction as part of the root cause of aging: it limits cellular energy and raises oxidative stress, and immune cells are especially vulnerable to decline and 'exhaustion.'
12 interventions act here
Glycine
Amino acid that supports glutathione production with NAC and may deepen slow-wave sleep.
I've used it
Methylene Blue
Century-old dye and drug that shuttles electrons in mitochondria; low doses studied for Alzheimer's.
Watching
N-acetylcysteine (NAC)
Cysteine source that cells use to make glutathione, the antioxidant that declines with age.
I've used it
NAD+ precursors (NR, NMN) and CD38 inhibition
NR and NMN feed the NAD+ salvage pathway to offset the age-related NAD+ decline driven partly by CD38.
In my stack
Taurine
Sulfur-containing amino acid whose levels decline with age; supplementation extended median lifespan in mice.
I've used it
L-Glutamine
Abundant amino acid fueling gut lining cells and mucus; she takes it to protect the gut barrier.
In my stack
Proline
Collagen-rich amino acid that restored mitochondrial function in senescent stem cells in a 2024 study.
In my stack
Spermidine
Polyamine that induces autophagy and declines with age; extends lifespan in model organisms.
Watching
Alpha-Ketoglutarate (AKG)
Krebs-cycle metabolite that drops sharply with age; supplementation extended lifespan and healthspan in mice.
In my stack
Urolithin A
Gut-microbe metabolite of ellagitannins that boosts mitophagy and may counter age-related immune decline.
In my stack
Microplastics Reduction
Cutting nanoplastic exposure, found in arterial plaque and brain tissue, and keeping the gut barrier strong.
I've used it
Luteolin
Flavonoid from herbs and vegetables with anti-inflammatory, antihistamine, and possibly neuroprotective effects, mostly shown in cells and animals.
Watching