Gut microbiome
Gut microbes make metabolites that can protect (bifidobacteria, 5-AVAB, arginine) or harm (imidazole propionate), shaping immune balance, heart, and brain health; modern exposures like artificial sweeteners shift the microbiome.
7 interventions act here
C15:0 (Pentadecanoic Acid)
Odd-chain saturated fat linked to better metabolic and heart health in observational studies; supplement trials show minimal effect.
Skeptical
Arginine
Semi-essential amino acid that fuels T cells and feeds spermidine; reduced amyloid-beta in Alzheimer's mice.
In my stack
L-Glutamine
Abundant amino acid fueling gut lining cells and mucus; she takes it to protect the gut barrier.
In my stack
Light at Night & Melatonin
Bright days and dark nights maximize melatonin, an antioxidant linked to lower mortality and Alzheimer's protection.
I've used it
Spermidine
Polyamine that induces autophagy and declines with age; extends lifespan in model organisms.
Watching
Urolithin A
Gut-microbe metabolite of ellagitannins that boosts mitophagy and may counter age-related immune decline.
In my stack
Microplastics Reduction
Cutting nanoplastic exposure, found in arterial plaque and brain tissue, and keeping the gut barrier strong.
I've used it