Methylation & homocysteine
The methylation cycle supplies methyl groups for gene regulation and creatine synthesis (about 40% of them go to creatine); B12, B6, and folate help keep homocysteine, a heart and brain risk marker, in check.
5 interventions act here
Folate & B Vitamins
Methylation-cycle vitamins that lower homocysteine and slowed brain atrophy in MCI, but excess folate may fuel cancer.
In my stack
Creatine
Cheap energy-buffering supplement studied for brain function, vascular health and lowering homocysteine.
In my stack
Methionine & Sulfur Amino Acid Restriction
Limiting methionine and cysteine extends lifespan in animals and lowers IGF-1; intermittent versions may spare muscle.
Watching
Spermidine
Polyamine that induces autophagy and declines with age; extends lifespan in model organisms.
Watching
Alpha-Ketoglutarate (AKG)
Krebs-cycle metabolite that drops sharply with age; supplementation extended lifespan and healthspan in mice.
In my stack