Longevity LifehacksEvidence Map
Mechanisms/Lipids & membranes
Mechanism

Lipids & membranes

Membrane lipids matter: plasmalogens act as brain antioxidant phospholipids and are very low in Alzheimer's, C15:0 is thought to stabilize cell membranes, and the omega-6 to omega-3 balance shapes inflammation.

Alzheimer's & cognitive agingInflammaging & immune agingGut barrier & microbiomeHeart & metabolic healthMuscle, skin & physical aging

4 interventions act here

Omega-3s (DHA/EPA) & SPMs DHA and EPA are the building blocks for pro-resolving mediators that actively switch off inflammation. Supplement InflammagingAlzheimer'sHeartMuscle, skin 14 posts
Trial4
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In my stack
Taurine Sulfur-containing amino acid whose levels decline with age; supplementation extended median lifespan in mice. Amino acid HeartMuscle, skinInflammaging 5 posts
Trial4
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I've used it
C15:0 (Pentadecanoic Acid) Odd-chain saturated fat linked to better metabolic and heart health in observational studies; supplement trials show minimal effect. Supplement HeartGut barrierInflammaging 1 posts
Trial3
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Skeptical
Plasmalogens Membrane phospholipids that act as the brain's last-line antioxidant; levels are very low in Alzheimer's. Supplement Alzheimer's 2 posts
Trial3
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Watching