Immune aging & T cells
The thymus shrinks with age, weakening T cells against infection and cancer; she highlights arginine as fuel for T cell metabolism and red-light therapy as a way to support immune function.
6 interventions act here
Vitamin D3 (incl. HMB + vitamin D)
Sunlight-made hormone that regulates immunity and muscle; linked to slower telomere shortening and preserved function in trials.
I've used it
NAD+ precursors (NR, NMN) and CD38 inhibition
NR and NMN feed the NAD+ salvage pathway to offset the age-related NAD+ decline driven partly by CD38.
In my stack
Arginine
Semi-essential amino acid that fuels T cells and feeds spermidine; reduced amyloid-beta in Alzheimer's mice.
In my stack
Spermidine
Polyamine that induces autophagy and declines with age; extends lifespan in model organisms.
Watching
Alpha-Ketoglutarate (AKG)
Krebs-cycle metabolite that drops sharply with age; supplementation extended lifespan and healthspan in mice.
In my stack
Urolithin A
Gut-microbe metabolite of ellagitannins that boosts mitophagy and may counter age-related immune decline.
In my stack