Amyloid & tau
Amyloid-beta plaques and tau tangles define Alzheimer's, but she frames them as possibly an innate immune defense against pathogens, with blood-brain barrier leakiness, fibrinogen, and GSK3β acting upstream.
11 interventions act here
Omega-3s (DHA/EPA) & SPMs
DHA and EPA are the building blocks for pro-resolving mediators that actively switch off inflammation.
In my stack
Glycine
Amino acid that supports glutathione production with NAC and may deepen slow-wave sleep.
I've used it
N-acetylcysteine (NAC)
Cysteine source that cells use to make glutathione, the antioxidant that declines with age.
I've used it
NAD+ precursors (NR, NMN) and CD38 inhibition
NR and NMN feed the NAD+ salvage pathway to offset the age-related NAD+ decline driven partly by CD38.
In my stack
Plasmalogens
Membrane phospholipids that act as the brain's last-line antioxidant; levels are very low in Alzheimer's.
Watching
Arginine
Semi-essential amino acid that fuels T cells and feeds spermidine; reduced amyloid-beta in Alzheimer's mice.
In my stack
Light at Night & Melatonin
Bright days and dark nights maximize melatonin, an antioxidant linked to lower mortality and Alzheimer's protection.
I've used it
Methionine & Sulfur Amino Acid Restriction
Limiting methionine and cysteine extends lifespan in animals and lowers IGF-1; intermittent versions may spare muscle.
Watching
Lithium (low-dose lithium orotate)
Trace mineral found in food and water; low brain lithium is linked to Alzheimer's amyloid, tau, and neuroinflammation.
In my stack
Microplastics Reduction
Cutting nanoplastic exposure, found in arterial plaque and brain tissue, and keeping the gut barrier strong.
I've used it
Luteolin
Flavonoid from herbs and vegetables with anti-inflammatory, antihistamine, and possibly neuroprotective effects, mostly shown in cells and animals.
Watching