Nutrient sensing & mTOR
Animal studies suggest restricting specific amino acids (methionine, cysteine, BCAAs such as valine), rather than calories alone, drives longevity; the gut metabolite imidazole propionate activates mTORC1 and impairs insulin signaling.
2 interventions act here
Methionine & Sulfur Amino Acid Restriction
Limiting methionine and cysteine extends lifespan in animals and lowers IGF-1; intermittent versions may spare muscle.
Watching
Luteolin
Flavonoid from herbs and vegetables with anti-inflammatory, antihistamine, and possibly neuroprotective effects, mostly shown in cells and animals.
Watching