Spermidine and Healthspan

From extending healthspan to improving vaccine efficacy in older adults, spermidine is a biogenic amine with many possible anti-aging benefits. I’ll dig into the research on the topic, explore the clinical trials, and explain why increasing spermidine can sometimes be a bad idea. This one ‘supplement’ is essential to go beyond the headlines and understand … Read More

Low dose lithium reduces cellular senescence

A recent study shows that low-dose lithium may act as a senolytic.[ref] This has important implications in healthy aging – including preventing mortality from respiratory diseases, such as COVID, and neurodegenerative diseases like Alzheimer’s. First, let me go into a little background information on lithium and then cellular senescence. Next, I’ll explain the new study … Read More

Preventing muscle loss in aging

Kind of like pornography, we all know aging when we see it. There is a specific point when suddenly someone looks old. Like they have crossed some invisible threshold, moving from healthy and older into the twilight area at the end of life. I’m not talking about gray hair or laugh lines that became more … Read More

Glycine for improving slow-wave (deep) sleep

A recent study on sleep and dementia points out (once again) that sleep is essential for good health in aging. The study found that decreased sleep, such as 6 hours or less per night, during your 50s and 60s increases the risk of dementia in your later decades by 30%. Quality sleep is foundational for … Read More

Supplementing with Glycine and NAC: reduce oxidative stress, increase mitochondrial function

glycine and NAC for longevity

Mitochondrial dysfunction and elevated oxidative stress are part of the root cause of aging. With poor mitochondrial function, cells can’t perform at an optimal level, leading to an increase in ROS (reactive oxygen species). Oxidative stress, due to an increase in ROS, increases the risk of cognitive decline, inflammation, heart disease, and insulin resistance. So … Read More

Lithium orotate: A natural mineral that affects mood, Alzheimer’s disease, and aging

I read a lot of studies on health and genetics, and I keep finding research on the mineral lithium popping up. Topics such as circadian rhythm dysfunction, Alzheimer’s disease, telomere length, type 2 diabetes, and obesity…all linking to lithium? The rest of this article explains the research showing the importance of this mineral in our … Read More

TNF-alpha and Inflammaging

TNF-alpha (tumor necrosis factor alpha) is a proinflammatory cytokine upregulated in aging. TNF-alpha acts as a signaling molecule in our immune system and is important in our innate immune response. But chronically elevated TNF-alpha is one cause of the diseases of aging. Inhibiting chronic inflammation is one tool available for longevity and healthspan. This article … Read More

Targeting cellular senescence with natural compounds

Cellular senescence is a natural process that stops the reproduction of cells. While senescence happens throughout life, in aging, an accumulation of excess senescent cells seems to be at the heart of many age-related diseases. What is cellular senescence? Senescence is when a cell can no longer divide and has been damaged — but yet … Read More

Alzheimer’s prevention through targeting the liver

Preventing Alzheimer’s is at the top of the list for many people when considering longevity and healthspan. Genetics, as well as environmental factors, play into the susceptibility to this disease of aging. While most focus is on the brain, recent research shows points to another key player in Alzheimer’s prevention: the liver! Bile acids, Alzheimer’s, … Read More

Luteolin: neuroprotective and anticancer flavonoid

Luteolin is a flavonoid found in herbs and vegetables. Research shows that it has numerous anti-inflammatory and antimicrobial effects. Additionally, some research shows that luteolin may help to stop the proliferation of certain cancer cells. The goal here is to simply present a balanced view of the studies and clinical trials on luteolin as a … Read More