Targeting cellular senescence with natural compounds

Cellular senescence is a natural process that stops the reproduction of cells. While senescence happens throughout life, in aging, an accumulation of excess senescent cells seems to be at the heart of many age-related diseases. What is cellular senescence? Senescence is when a cell can no longer divide and has been damaged — but yet … Read More

Luteolin: neuroprotective and anticancer flavonoid

Luteolin is a flavonoid found in herbs and vegetables. Research shows that it has numerous anti-inflammatory and antimicrobial effects. Additionally, some research shows that luteolin may help to stop the proliferation of certain cancer cells. The goal here is to simply present a balanced view of the studies and clinical trials on luteolin as a … Read More

Metformin: Longevity research and genetics

A decades-old diabetes drug now holds promise for increasing healthspan. Research shows that metformin may reduce the risk of some of the diseases of aging, thus increasing the number of years someone is healthy. What is metformin? Metformin, also known as Glucophage, is the most commonly prescribed medication for reducing blood glucose levels. Metformin prescriptions … Read More

GHK Peptide: neurogenesis, skin, and more

GHK-Cu is a tiny little peptide that can be absorbed transdermally. It is often advertised as a way to reduce skin aging. While there are some good studies on it as a ‘beauty’ product, that is just the tip of the GHK-Cu iceberg. Let’s dive into the science of what this little peptide can do … Read More

Vitamin D for preventing respiratory infections

Have you ever wondered why you are much more likely to have a cold in the winter than in the summer? It turns out that researchers have puzzled over the seasonality of respiratory viruses for decades. In 1926, one scientist proposed that the seasonality was due to the vitamin found in dairy products and produced … Read More

MOTS-c: mitochondrial peptide that mimics exercise

A recent study in the journal Nature explains the latest research on a fascinating peptide known as MOTS-c. A little background first: Small peptide molecules are made up of 2-50 amino acids. Amino acids also makeup protiens but in chains longer than 50. Mitochondria are the organelles responsible for energy production in your cells. And … Read More

Boosting NAD+: amyloid proteins and mitochondrial dysfunction in muscles

A recent study in Cell reported on experiments regarding mitochondrial function and amyloid protein accumulation in the muscles.[ref] The researchers used animal models and human muscle tissue to determine that amyloid-like protein deposits occur in muscle during aging. Amyloid proteins are aggregates of proteins that fold into long fibers. Perhaps the most well-known is amyloid-beta, … Read More

Calculating Biological Age

Calculators for predicting biological age: The idea of biological age is that it shows how your lifestyle and genetics interact to estimate your cellular age more accurately than what the calendar says (chronological age). These biological age calculators are based on algorithms created using large population data sets and mortality outcomes. 1) – You … Read More

Hallmarks of Aging

A 2013 paper in the journal Cell defines the way we think of aging as a disease. In the paper, the authors break down the process of aging into what they called the ‘Hallmarks of Aging’. It is essentially a schematic of how to organize the processes that cause aging. I’m going to explain the … Read More

Longevity Genes

There are several genes known as “longevity” genes. Specific variants of these genes have an association with an increased likelihood of living to be 100 or more. And…more importantly, these genetic variants have links to a longer ‘healthspan’. Longevity: The term longevity refers to lifespan. People in the US, on average, live to a little … Read More