Methylene Blue: Mitochondrial function, cognitive benefits?

Methylene blue (Methylthioninium chloride) has been used in pharmacology for over a century. It is a fascinating compound that was first synthesized as a blue dye. In 1891, it was discovered that it could treat malaria. It is also used as a stain for microscope slides.[ref] Currently, methylene blue is an FDA-grandfathered drug. It is … Read More

Genetics and Healthspan: Teasing out what is important

Genetic studies, especially large genome-wide association studies, can be informative when looking at what is really important for healthspan. Essentially, these types of studies look to see which genetic variants are linked to outcomes — real-life people, real outcomes, and large data sets. A new study recently published in Nature Medicine estimated the effects of … Read More

Spermidine and Healthspan

From extending healthspan to improving vaccine efficacy in older adults, spermidine is a biogenic amine with many possible anti-aging benefits. I’ll dig into the research on the topic, explore the clinical trials, and explain why increasing spermidine can sometimes be a bad idea. This one ‘supplement’ is essential to go beyond the headlines and understand … Read More

Senolytics for COVID and other respiratory illnesses?

New research on COVID-19 shows the important role of cellular senescence in the high mortality rates in the elderly. Elderly people are much more vulnerable to the flu, respiratory infections, and sepsis than middle-aged or younger adults. We all know that when grandma gets the flu in the nursing home, it is a serious matter. … Read More

Preventing muscle loss in aging

Kind of like pornography, we all know aging when we see it. There is a specific point when suddenly someone looks old. Like they have crossed some invisible threshold, moving from healthy and older into the twilight area at the end of life. I’m not talking about gray hair or laugh lines that became more … Read More

Alpha-ketoglutarate for longevity

alpha-ketoglutarate for longevity and healthspan

Alpha-ketoglutarate is a key molecule produced in your cells. Recently, research studies have shown that it may play a key role in healthy aging, including increasing healthspan and lifespan. What is alpha-ketoglutarate? Alpha-ketoglutarate (αKG) is a molecule that cells produce. It has several important functions in the body:[ref] It is involved in the Krebs cycle … Read More

Glycine for improving slow-wave (deep) sleep

A recent study on sleep and dementia points out (once again) that sleep is essential for good health in aging. The study found that decreased sleep, such as 6 hours or less per night, during your 50s and 60s increases the risk of dementia in your later decades by 30%. Quality sleep is foundational for … Read More

Supplementing with Glycine and NAC: reduce oxidative stress, increase mitochondrial function

glycine and NAC for longevity

Mitochondrial dysfunction and elevated oxidative stress are part of the root cause of aging. With poor mitochondrial function, cells can’t perform at an optimal level, leading to an increase in ROS (reactive oxygen species). Oxidative stress, due to an increase in ROS, increases the risk of cognitive decline, inflammation, heart disease, and insulin resistance. So … Read More

Lithium orotate: A natural mineral that affects mood, Alzheimer’s disease, and aging

I read a lot of studies on health and genetics, and I keep finding research on the mineral lithium popping up. Topics such as circadian rhythm dysfunction, Alzheimer’s disease, telomere length, type 2 diabetes, and obesity…all linking to lithium? The rest of this article explains the research showing the importance of this mineral in our … Read More

TNF-alpha and Inflammaging

TNF-alpha (tumor necrosis factor alpha) is a proinflammatory cytokine upregulated in aging. TNF-alpha acts as a signaling molecule in our immune system and is important in our innate immune response. But chronically elevated TNF-alpha is one cause of the diseases of aging. Inhibiting chronic inflammation is one tool available for longevity and healthspan. This article … Read More